Diagnosis of cerebral toxoplasmosis

Immunopathogenesis of cerebral toxoplasmosis.

Interferon (IFN)-gamma is an absolute requirement for resistance against acute acquired infection with Toxoplasma gondii and development of toxoplasmic encephalitis (TE) during the late stage of infection. Multiple populations of both T and non-T cells are important sources of IFN-gamma in resistance. In the absence of IFN-gamma-producing non-T cells, T cells cannot prevent TE. Interleukin-12, ...

Features to validate cerebral toxoplasmosis.

INTRODUCTION Neurotoxoplasmosis (NT) sometimes manifests unusual characteristics. METHODS We analyzed 85 patients with NT and AIDS according to clinical, cerebrospinal fluid, cranial magnetic resonance, and polymerase chain reaction (PCR) characteristics. RESULTS In 8.5%, focal neurological deficits were absent and 16.4% had single cerebral lesions. Increased sensitivity of PCR for Toxoplas...

Ly6C Monocytes Control Cerebral Toxoplasmosis

The laboratory diagnosis of toxoplasmosis.

A case of congenital toxoplasmosis has recently been seen in this hospital The patient, a girl aged 5 years, presented with hydrocephalus, bilateral pes cavus, and blindness. The eyes showed extensive retinochoroiditis thought to be characteristic of toxoplasmosis. Radiographs of the skull showed areas of cerebral calcification. Two years before the birth of the patient the mother had suffered ...

Laboratory Diagnosis of Congenital Toxoplasmosis

Recent studies have demonstrated that screening and treatment for toxoplasmosis during gestation result in a decrease of vertical transmission and clinical sequelae. Early treatment was associated with improved outcomes. Thus, laboratory methods should aim for early identification of infants with congenital toxoplasmosis (CT). Diagnostic approaches should include, at least, detection of Toxopla...